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Epithelial Cell Infection Analyses with Shigella

Epithelial Cell Infection Analyses with Shigella

Published on: February 9, 2024

Decrease in shigellosis-related deaths without Shigella spp.-specific interventions, Asia.

Pradip Bardhan¹, A S G Faruque, Aliya Naheed

¹International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.

Emerging Infectious Diseases

|October 30, 2010

Summary

Shigellosis deaths in Asia have decreased by 98% since the late 1990s, with significantly lower case-fatality rates. This decline occurred without specific Shigella interventions, suggesting broader public health measures may be responsible.

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Area of Science:

Infectious Diseases
Public Health
Epidemiology

Background:

Previous literature (1966-1997) estimated ~1.1 million annual shigellosis deaths globally.
Asia accounted for a significant portion of these deaths, with ~880,000 fatalities.

Purpose of the Study:

To assess current annual shigellosis incidence and mortality in Asia.
To compare recent estimates with historical data and identify trends in case-fatality rates.

Main Methods:

A comprehensive review of scientific literature from 1990-2009.
Analysis of global and regional data on shigellosis cases and deaths.

Main Results:

An estimated 125 million annual shigellosis cases in Asia (1990-2009).
Approximately 14,000 annual shigellosis deaths in Asia, a 98% reduction compared to earlier estimates.
Reduced mortality is attributed to lower case-fatality rates, not fewer infections.

Conclusions:

Shigellosis-related mortality in Asia has dramatically decreased.
Nonspecific public health interventions like measles vaccination, vitamin A supplementation, and improved nutrition are potential contributors to this decline.
Further research is needed to confirm the impact of these nonspecific interventions on shigellosis outcomes.