[Relationship between expression of lung resistance protein gene and clinical pathophysiological characteristics of
1Respiratory Disease Research Center , Beijing Red-Cross Chaoyang Hospital Affiliated to Capital University of Medical Science, Beijing 100020, P. R. China.
Background:
To study the relationship between lung resistance protein gene (LRP) expression and clinical pathophysiological characteristics of lung cancer.
Methods:
Expression of LRP gene was determined in 49 lung cancer samples and 41 corresponding paracancerous tissues by RT-PCR.
Results:
LRP was expressed in lung cancers and corresponding paracancerous tissues. The positive expression rate was 63. 3%( 31/ 49) in cancer tissues and 21. 9% ( 9/ 41) in corresponding paracancerous tissues respectively ( P< 0. 01) . The positive rate in NSCLC ( 29/ 41, 70. 7%)was significantly higher than that in SCLC ( 2/ 8, 25%) ( P < 0. 05) , and the positive rate in adenocarcinoma ( 11/ 12, 91. 7%) was also remarkably higher than that in squamous cell carcinoma ( 11/ 22, 50%) ( P < 0. 05) . In addition, LRP expression in the smokers ( 26/ 35, 74. 3%) was significantly higher than that in the non-smokers ( 5/ 14, 35. 7%) ( P< 0. 05) .
Conclusions:
The expression of LRP may be related to drug resistance of lung cancer, and smoking may increase LRP gene expression.
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