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Egg's ZP3 structure speaks volumes
Paul M Wassarman1, Eveline S Litscher
1Department of Developmental and Regenerative Biology, Mount Sinai School of Medicine, New York, NY 10029, USA. paul.wassarman@mssm.edu
Cell
|October 30, 2010
Abstract:
Binding of mammalian sperm to eggs depends in part on ZP3, a glycoprotein in the egg's extracellular coat, the zona pellucida. In this issue, Han et al. (2010) describe the structure of an avian ZP3 homolog, providing insights into ZP3 processing and polymerization and the roles of the ZP3 polypeptide and its carbohydrate in sperm binding.

