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Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons
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Chemoaffinity revisited: dscams, protocadherins, and neural circuit assembly

S Lawrence Zipursky1, Joshua R Sanes

  • 1Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, 90095, USA. lzipursky@mednet.ucla.edu

Cell
|October 30, 2010
PubMed
Summary

Neural circuits assemble via molecular labels on axons and targets. Drosophila Dscams and vertebrate clustered protocadherins (Pcdhs) are key candidates, but their combinatorial expression may challenge traditional assembly views.

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