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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Effect of biventricular pacing on diastolic dyssynchrony

Miriam Shanks1, Matteo Bertini, Victoria Delgado

  • 1Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

Journal of the American College of Cardiology
|October 30, 2010
PubMed

Insights

Cardiac resynchronization therapy (CRT) improves diastolic dyssynchrony in heart failure patients who respond to treatment. Non-responders showed less baseline diastolic dyssynchrony, and it did not improve after CRT.

Area of Science:

  • Cardiology
  • Heart Failure Research
  • Medical Imaging

Background:

  • Diastolic dyssynchrony in heart failure (HF) is not well understood.
  • The impact of cardiac resynchronization therapy (CRT) on diastolic dyssynchrony requires further investigation.

Purpose of the Study:

  • To investigate the changes in diastolic dyssynchrony in heart failure patients undergoing CRT.
  • To compare diastolic dyssynchrony between CRT responders and non-responders.

Main Methods:

  • 266 heart failure patients were assessed using color-coded tissue Doppler imaging at baseline, 48 hours, and 6 months post-CRT.
  • Diastolic dyssynchrony was defined as the maximal time delay in early diastolic velocities in basal left ventricular segments.
  • CRT responders were identified by a ≥15% decrease in left ventricular end-systolic volume at 6 months.

Main Results:

  • At baseline, diastolic dyssynchrony (51.9%) was more prevalent than systolic dyssynchrony (46.2%).
  • CRT responders exhibited significantly longer baseline systolic and diastolic delays compared to non-responders.
  • Both systolic and diastolic delays significantly improved in responders at 48 hours and 6 months post-CRT, but not in non-responders.

Conclusions:

  • Diastolic dyssynchrony is common in heart failure patients and is more pronounced in CRT responders.
  • CRT effectively improves diastolic dyssynchrony, but only in patients who respond to the therapy.
  • Understanding the pathophysiology of diastolic dyssynchrony and its response to CRT can inform personalized patient treatments.
Abstract

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