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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

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Related Experiment Video

Updated: Jun 7, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Low bone mineral density in rotating-shift workers.

Ivan Quevedo1, Ana M Zuniga

  • 1Division of Endocrinology, University of Concepcion, Concepcion, Chile. equevedo@udec.cl

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
|October 30, 2010
PubMed
Summary
This summary is machine-generated.

Rotating shift work is linked to lower bone mineral density (BMD) and increased osteoporosis risk in postmenopausal nurses. This study suggests shift work may be a novel risk factor for osteoporosis.

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Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

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Last Updated: Jun 7, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

Area of Science:

  • Occupational Health
  • Endocrinology
  • Bone Metabolism

Background:

  • Shift work is associated with increased bone resorption.
  • Previous research has not established a link between shift work and reduced bone mineral density (BMD).

Purpose of the Study:

  • To investigate the association between rotating-shift work schedules and low BMD.
  • To test the hypothesis that rotating shift work is a risk factor for osteoporosis.

Main Methods:

  • A comparative study involving 70 postmenopausal nurses (39 rotating shift, 31 daytime).
  • Data collection included medical history, health examination, behavioral questionnaires, biochemical markers, and BMD measurements.
  • Participants were categorized based on their work schedule.

Main Results:

  • Rotating-shift workers exhibited significantly lower BMD in the lumbar spine and femoral neck compared to daytime workers.
  • Osteoporosis was diagnosed in 25.6% of rotating-shift workers, while none were found in the daytime group.
  • Rotating-shift workers showed a higher prevalence of osteopenia.

Conclusions:

  • Rotating-shift work is associated with reduced BMD in both trabecular and cortical bone.
  • This study identifies rotating shift work as a potential new risk factor for osteoporosis.
  • Further research is needed to confirm these findings in diverse populations.