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Viable skin efficiently absorbs and metabolizes bisphenol A
Daniel Zalko1, Carine Jacques, Hélène Duplan
1INRA, UMR1089 Xénobiotiques, 180 Chemin de Tournefeuille, BP 93173, 31027 Toulouse Cedex 3, France. dzalko@toulouse.inra.fr
Chemosphere
|October 30, 2010
Summary
Skin contact readily absorbs and metabolizes bisphenol A (BPA). This research confirms the trans-dermal route significantly contributes to human BPA exposure from direct contact.
Area of Science:
- Toxicology
- Dermatology
- Environmental Health
Background:
- Skin contact is a potential exposure route for bisphenol A (BPA).
- Understanding BPA's fate in skin is crucial for assessing human exposure risks.
Purpose of the Study:
- To investigate the absorption and metabolism of BPA through viable human and pig skin models.
- To quantify BPA diffusion and identify its metabolites in skin.
Main Methods:
- Utilized viable human skin explants and pig ear skin cultures.
- Applied radiolabeled BPA (14C-BPA) to skin surfaces.
- Measured radioactivity distribution and quantified BPA and metabolites using radio-HPLC.
Main Results:
- BPA was efficiently absorbed by viable skin models (pig: 65%, human: 46%).
- Extensive BPA metabolism occurred only in viable skin systems.
- Major metabolites identified were BPA mono-glucuronide and BPA mono-sulfate.
Conclusions:
- Viable skin models confirm ready absorption and metabolism of BPA.
- The trans-dermal route is a significant contributor to human BPA exposure.
- Metabolism significantly reduces free BPA levels in the skin.
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