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Published on: February 16, 2015
[Unknown gonadotoxicity chemotherapy and preservation of fertility: example of Temozolomide]
L Sitbon Sitruk1, M Sanson, M Prades
1Unité fonctionnelle de biologie de la reproduction, groupe hospitalier Pitié-Salpêtrière, université Paris VI, 47-83, boulevard de l'Hôpital, 75013 Paris, France. lesliesitbon@hotmail.com
Objectives:
To evaluate the effect of Temozolomide on female fertility and the relevance of our coverage in preservation of fertility.
Patients And Methods:
From 2005 to 2009, 24 patients treated with Temozolomide for a low-grade glioma were included in the study (12 women who underwent a fertility preservation consultation and 12 women who did not). A retrospective study of their medical records and sending a questionnaire were undertaken to assess their fertility after treatment.
Results:
Of the 24 patients, 15 patients had no fertility preservation and the remaining nine had a cryopreservation of embryos with or without an oocyte cryopreservation. Four patients are or have been pregnant (delivery, spontaneous miscarriage, pregnancy being in the group of preserving fertility and a current pregnancy in the group where no fertility preservation has been achieved).
Discussion:
First study on the effect of Temozolomide on female fertility.
Conclusion:
Temozolomide is not totally gonadotoxic.
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