Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brick Cutting Techniques01:08

Brick Cutting Techniques

Brick-cutting techniques involve various tools and methods to shape bricks for construction. A mason's hammer with a chisel-pointed end is used for basic shaping through sharp, precise strikes. For more complex shapes requiring higher precision, a power saw with a water-cooled diamond blade is used.
Cut bricks are categorized by size. Bricks cut to half their original length are called half-bats, while those cut to three-fourths their length are known as three-fourth bats.
Special types of cut...
Veins of Upper Limbs01:17

Veins of Upper Limbs

The human circulatory system, a marvel of biological engineering, is a complex network of vessels that transport blood throughout the body. Among these, the veins responsible for carrying blood from the upper limbs are divided into two categories: deep and superficial.
The deep venous system is primarily composed of the ulnar and radial veins. The ulnar vein, which drains the fingers through the superficial palmar venous arches, and the radial vein, which serves the palms via the deep palmar...
Endoscopic Procedures V: ERCP01:26

Endoscopic Procedures V: ERCP

Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
Endoscopic Procedures III: Video Capsule Endoscopy01:28

Endoscopic Procedures III: Video Capsule Endoscopy

Capsule endoscopy, or wireless or video capsule endoscopy, is a diagnostic procedure for examining the entire gastrointestinal tract. Patients swallow a capsule about the size of a vitamin tablet. The capsule is equipped with a transmitter, a battery, an LED light source, and a color video camera to capture images throughout the gastrointestinal tract. This procedure is particularly useful for diagnosing conditions such as Crohn's disease, ulcerative colitis, tumors, polyps, ulcers, unexplained...
Veins of Head and Neck01:19

Veins of Head and Neck

The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
Veins of the Abdomen and Pelvis01:18

Veins of the Abdomen and Pelvis

The human body is a complex system of interconnected parts, and the circulatory system plays a crucial role in maintaining overall health. One key component of this system is the inferior vena cava, a large vein responsible for returning blood from the abdominopelvic viscera and abdominal walls to the heart.
The inferior vena cava is fed by numerous smaller veins. The lumbar veins, for instance, drain the posterior abdominal wall, emptying both directly into the inferior vena cava and into the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transfusing HPA-mismatched platelets to mimic fetomaternal hemorrhage elicits fetal/neonatal alloimmune thrombocytopenia.

Blood·2026
Same author

Structural basis of HPA-1a alloimmunization in FNAIT and allosteric regulation of integrin conformation.

Blood·2026
Same author

Differentiating pathogenic from bystander autoantibodies in immune thrombocytopenia using intact glycoproteindeficient megakaryocytes.

Haematologica·2025
Same author

In pursuit of FNAIT biomarkers: αVβ3 specificity falls short.

Blood·2025
Same author

Relieving platelet inhibition using a novel bispecific antibody: a novel approach for circumventing the platelet storage lesion.

Journal of thrombosis and haemostasis : JTH·2025
Same author

Relieving platelet inhibition using a novel bi-specific antibody: A novel approach for circumventing the platelet storage lesion.

bioRxiv : the preprint server for biology·2025
Same journal

Decentralized Clinical Trials in Hematology: the Promise and the Peril.

Blood·2026
Same journal

How I Treat Chemotherapy-Induced Thrombocytopenia with Thrombopoietin Receptor Agonists.

Blood·2026
Same journal

The Chaos of Choice in Large B-cell Lymphoma: A Call to Harmonize First-line Trial Design.

Blood·2026
Same journal

Precision Transfusion Medicine in the Omics Era.

Blood·2026
Same journal

Fibrocytes drive JAK2V617F-mutated myelofibrosis: pitavastatin reverses marrow fibrosis and anemia.

Blood·2026
Same journal

Identifying steroid-refractory aGVHD before it happens.

Blood·2026
See all related articles

Related Experiment Video

Updated: Jun 7, 2026

Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain
17:13

Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain

Published on: October 22, 2017

GPVI and the not so eager cleaver.

Peter J Newman1

  • 1Bloodcenter of Wisconsin, USA.

Blood
|October 30, 2010
PubMed
Summary
This summary is machine-generated.

Platelets regulate their function by shedding surface receptors. New research using genetically modified mice reveals the complex molecular mechanisms behind this essential process, known as ectodomain shedding.

More Related Videos

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
09:04

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg

Published on: November 19, 2019

Extraction and Dissection of the Domesticated Pig Brain
09:16

Extraction and Dissection of the Domesticated Pig Brain

Published on: April 25, 2021

Related Experiment Videos

Last Updated: Jun 7, 2026

Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain
17:13

Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain

Published on: October 22, 2017

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
09:04

Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg

Published on: November 19, 2019

Extraction and Dissection of the Domesticated Pig Brain
09:16

Extraction and Dissection of the Domesticated Pig Brain

Published on: April 25, 2021

Area of Science:

  • Hematology
  • Molecular Biology
  • Cell Biology

Background:

  • Platelets play a crucial role in hemostasis and thrombosis.
  • Platelet responsiveness is modulated by the shedding of surface receptors.
  • The precise molecular mechanisms governing ectodomain shedding are not fully understood.

Discussion:

  • This study investigates the molecular players involved in platelet ectodomain shedding.
  • Researchers utilized genetically deficient mice to identify key proteases responsible for receptor shedding.
  • Findings highlight the intricate nature of ectodomain shedding in platelets.

Key Insights:

  • Specific proteases are critical for the shedding of adhesion and signaling receptors from platelets.
  • The process of ectodomain shedding is more complex than previously anticipated.
  • Understanding these mechanisms is vital for comprehending platelet function in health and disease.

Outlook:

  • Further research can elucidate the specific roles of identified proteases in platelet signaling.
  • This work may pave the way for novel therapeutic strategies targeting platelet-related disorders.
  • Future studies should explore the regulation and downstream effects of ectodomain shedding.