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Updated: Jun 7, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

Candida glabrata spinal osteomyelitis.

Natalie J M Dailey¹, Edward J Young

¹Michael E. DeBakey Veterans Affairs Medical Center, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA. janine.dailey@dhhs.nc.gov

The American Journal of the Medical Sciences

|October 30, 2010

Summary

This summary is machine-generated.

Invasive Candida glabrata infection can affect the spine, causing osteomyelitis and epidural abscesses. Successful treatment involves antifungal therapy and sometimes surgery for spinal complications.

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Last Updated: Jun 7, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

Area of Science:

Medical Mycology
Infectious Diseases
Neurosurgery

Background:

Invasive fungal infections, particularly candidiasis, are increasing due to immunosuppressive therapies.
Candida species are common causes of bloodstream infections and can disseminate to various organs.

Observation:

A case of spinal osteomyelitis and epidural abscess caused by Candida glabrata is presented.
The patient had a history of candidemia treated with fluconazole three months prior.

Findings:

The spinal infection was successfully treated with amphotericin B.
The patient later developed spondylolisthesis with cauda equina impingement, necessitating surgical intervention.

Implications:

This case highlights the potential for Candida glabrata to cause severe invasive spinal infections.
Aggressive antifungal treatment and consideration of surgical management are crucial for favorable outcomes in such cases.
Immunocompromised patients require vigilant monitoring for disseminated fungal infections.