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Updated: Jun 7, 2026
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Induction chemoradiation therapy with cisplatin plus irinotecan followed by surgical resection for superior sulcus
Katsuhiko Shimizu1, Masao Nakata, Ai Maeda
1Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Kawasaki Medical School, Okayama, Japan.
Purpose:
In this study, we retrospectively evaluate the safety and efficacy of induction chemoradiation using cisplatin plus irinotecan followed by surgical resection for superior sulcus tumor (SST).
Methods:
We reviewed the records of four patients with solitary, previously untreated T3-4, N0-1 superior sulcus nonsmall cell lung cancers. Patients received two cycles of chemotherapy, cisplatin and irinotecan, every 4 weeks. Radiotherapy directed at the tumor was administered with a split schedule at the total dose of 40 Gy in 20 fractions. Thoracotomy was performed 4 weeks after completion of the chemoradiation.
Results:
The toxicities of chemoradiation were mainly hematologic and were well-tolerated. Complete resection could be performed in all cases, and there was no postoperative mortality. At present, all the patients remain alive, and one has a local recurrence.
Conclusion:
This trimodality approach is a safe and effective approach for the local control of SST. Further studies are necessary to confirm the results.
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