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Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Overview of Metabolism01:40

Overview of Metabolism

Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Introduction to Metabolism01:30

Introduction to Metabolism

Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

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Related Experiment Video

Updated: Jun 7, 2026

Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry
07:25

Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

Published on: January 5, 2021

A network perspective on metabolism and aging.

Quinlyn A Soltow1, Dean P Jones, Daniel E L Promislow

  • 1Department of Medicine, Emory University, Atlanta, GA 30322, USA. promislow@uga.edu

Integrative and Comparative Biology
|October 30, 2010
PubMed
Summary
This summary is machine-generated.

Aging

Related Experiment Videos

Last Updated: Jun 7, 2026

Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry
07:25

Quantitative Metabolomics of Saccharomyces Cerevisiae Using Liquid Chromatography Coupled with Tandem Mass Spectrometry

Published on: January 5, 2021

Area of Science:

  • Systems biology
  • Gerontology
  • Metabolomics

Background:

  • Aging involves complex genetic, biochemical, and metabolic changes.
  • Network analysis, applied to gene expression and protein interactions, has revealed age-related declines in connectivity.
  • Understanding the molecular basis of aging requires holistic approaches.

Purpose of the Study:

  • To advocate for the use of metabolic networks in aging research.
  • To explore how metabolite network analyses can elucidate age-related functional decline.
  • To integrate metabolomics with network analysis for a comprehensive understanding of aging.

Main Methods:

  • Systems biology approach
  • Network analysis of gene expression and protein-protein interactions
  • Metabolomic methods and metabolite network analyses

Main Results:

  • Network analysis is suitable for studying age-related functional decline.
  • Gene and protein networks show altered structure and connectivity with age.
  • Metabolomic network approaches offer fundamental insights into aging processes.

Conclusions:

  • Metabolic network analysis is crucial for understanding systematic declines in aging.
  • Integrating metabolomics with network analysis can reveal how metabolite interactions affect aging phenotype and function.
  • This approach expands upon genomics and proteomics to provide a more complete picture of aging.