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Updated: Jun 7, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
Tumour necrosis factor 308 polymorphisms and hepatocellular carcinoma risk: a meta-analysis
Yan-Mei Guo1, Wei-Yu Wei, Xi-Zhong Shen
1Department of Gastroenterology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Fenglin Road 180, Shanghai 200032, China.
Background/Aims:
To investigate the association of the common polymorphisms comprehensively defining the genetic variability of the TNFA-308G > A with HCC risk.
Methodology:
We performed a meta-analysis of 9 published studies that included 1362 cancer cases and 2426 controls. We used random-effect (RE) or fixed-effect (FE) odds ratios (ORs) and 95% confidence intervals (CIs) according to the studies' heterogeneity to assess the strength of the associations.
Results:
The overall results suggested that the TNFA-308 AA and AG variant genotypes were associated with a significantly increased risk of HCC in different genetic models (homozygote comparison: OR = 2.51,95% CI: 1.11-5.67, p heterogeneity = 0.905; heterozygote comparison: OR = 1.58, 95% CI: 1.00-2.50, p heterogeneity = 0.001; dominant model comparison: OR = 1.59, 95% CI: 1.00-2.53, p heterogeneity = 0.000; recessive model comparison: OR = 2.27, 95% CI: 1.01-5.12, p heterogeneity = 0.962; complete overdominant model comparison: OR = 1.57, 95% CI: 1.00-2.45. P heterogeneity = 0.001; and allele comparison: OR = 1.52, 95% CI: 1.01-2.28, p heterogeneity = 0.002. There was at some extent heterogeneity when analyses were performed in some models, and there was no publication bias.
Conclusions:
This meta-analysis supported that the TNFA-308 A allele is a risk factor for HCC development.
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