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Interactions of intermediate filaments with cell structures.

M Carmo-Fonseca¹, J F David-Ferreira

¹Instituto de Histologia e Embriologia, Faculdade de Medicina, Universidade de Lisboa, Portugal.

Electron Microscopy Reviews

|January 1, 1990

Summary

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Intermediate filaments (IF) form a cellular network, interacting with various cell components. These interactions suggest IF may play roles beyond structure, potentially in information transfer and gene expression control.

Area of Science:

Cell Biology
Cytoskeleton Research

Background:

Intermediate filaments (IF) are key cytoskeletal components in eukaryotic cells.
Nuclear lamins are IF-like proteins, supporting nuclear structure and chromatin attachment.

Purpose of the Study:

To investigate the interactions of intermediate filaments with cellular components.
To explore potential functional roles of intermediate filaments beyond structural support.

Main Methods:

Immunofluorescence microscopy.
Whole-mount electron microscopy.

Main Results:

Intermediate filaments form a cytoplasmic network surrounding the nucleus and extending to the cell surface.
Electron microscopy revealed interactions between IF and the nucleus, plasma membrane, other cytoskeletal elements, organelles, and ribonucleoproteins.

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Conclusions:

Intermediate filaments interact with diverse cellular structures.
These interactions suggest potential roles in cellular information transfer and gene expression regulation, warranting further investigation.