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Updated: Jun 7, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
[Basic principles of creation of multilevel multistage mathematical model of aging]
Abstract:
Current knowledge on the aging allows to elaborate approaches to the creation of multilevel model of multistage of human aging taking into consideration events during the aging at various levels of integration: molecular, cellular, tissue, organ, systemic, organism. The present paper have deals with main states of the mathematical model of multistage aging, principles of its construction, applicability and evaluation of its prognostic power. There are 3 levels of integrative systems: homeostatic (organismal), systemic and cellular-molecular. The definitions of normal and pathological aging are given. The samples of various patterns of aging under the influence of factors accelerating aging (constant illumination or alimentary obesity) or under the factors slowing down aging (treatment with metformin or melatonin) are discussed.
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