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[Osteoarthritis and cardiovascular diseases in elderly patients: clinical and pathogenetic interrelationship]

O I Mendel', A V Naumov, A L Vertkin

    Advances in Gerontology = Uspekhi Gerontologii
    |November 2, 2010
    PubMed

    Insights

    Osteoarthritis (OA) is common in the elderly and often co-occurs with cardiovascular disease. This review explores their link, suggesting inflammation and metabolic issues as potential causes, and discusses rational pharmacotherapy.

    Area of Science:

    • Gerontology
    • Rheumatology
    • Cardiology

    Context:

    • Osteoarthritis (OA) is a prevalent condition in the elderly population.
    • Poly-morbidities, or co-morbidities, are common in patients with OA.
    • Cardiovascular pathology frequently co-exists with OA.

    Purpose:

    • To analyze the association between osteoarthritis and cardiovascular pathology.
    • To investigate the potential etiopathogenic interrelations between OA and cardiovascular disease.
    • To discuss aggravating factors and rational pharmacotherapy for OA patients with somatic pathology.

    Summary:

    • OA is linked to increased mortality from cardiovascular pathology.
    • Potential shared pathways include chronic inflammation and metabolic disturbances.
    • Vascular pathology may influence OA progression, while NSAIDs pose cardiovascular risks.

    Impact:

    • Highlights the importance of considering cardiovascular health in OA management.
    • Suggests SYSADOA (glucosamine, chondroitin sulfate) as a rational pharmacotherapy option.
    • Emphasizes the need for careful pharmacotherapy to mitigate cardiovascular risks in OA patients.

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