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Updated: Jun 7, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
[Use of threshold of toxicological concern for chemical substances safety assessment]
Minglan Zheng1, Shaoying Zhou, Xuejun Liu
1School of Public Health/National Key Lab for Public Health Safety of MOH/WHO Collaborating Center for Occupational Health (Shanghai), Fudan University, Shanghai 200032, China. 09111020020@fudan.edu.cn
Abstract:
The threshold of toxicological concern (TTC) approach is a risk assessment tool of toxicology. When the exposure dose of human body is below the TTC of chemicals, the likelihood of that chemical causing negative influence on the human health is very low. Earliest, TTC approach was used in the risk assessment of in the respect of the food packing materials. Currently, TTC approach is used for safety assessment in the fields of food packing material, flavoring agents, medicine, industry chemicals, cosmetics, and etc. TTC approach provides useful assessment tool for the safety evaluation for the chemical substances.
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