Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Latent Factor Modeling Reveals Unexpected Spatial Heterogeneity in Human Alzheimer's Disease Brain Transcriptomes.

Computational and structural biotechnology journal·2026
Same author

Single-cell eQTL mapping reveals convergent glial-neuronal risk architecture in Parkinson's disease.

bioRxiv : the preprint server for biology·2026
Same author

Case Study 11: A 67-Year-Old Man With Behavioral Disturbances and Frequent Falls.

The Journal of neuropsychiatry and clinical neurosciences·2026
Same author

The words community dwelling, Spanish-preferring Mexican/Mexican American adults use to talk about Alzheimer's disease and genetic testing: Implications for education and outreach.

Alzheimer's & dementia (New York, N. Y.)·2026
Same author

Massive-scale single-nucleus multi-omics identifies novel rare noncoding drivers of Parkinson's disease.

bioRxiv : the preprint server for biology·2026
Same author

Systems genetic dissection of brain gene expression reveals excitotoxic mechanisms of Alzheimer's disease.

Molecular psychiatry·2026
Same journal

Basic Microglial Functions and How They Go Awry in Neurodegenerative Disease.

Annual review of pathology·2026
Same journal

Integration and Intersection of Cancer Metabolism with Epigenetic Pathways in Gliomas.

Annual review of pathology·2025
Same journal

The Role of Fibroblasts Across Inflammation and Immunity.

Annual review of pathology·2025
Same journal

The Role of MicroRNAs in Viral and Bacterial Infections.

Annual review of pathology·2025
Same journal

Role of Immune Cells in Hepatitis B Virus and Associated Sequelae.

Annual review of pathology·2025
Same journal

Pathology of the Coronary Arteries and Myocardium in Kawasaki Disease.

Annual review of pathology·2025
See all related articles

Related Experiment Video

Updated: Jun 7, 2026

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

Parkinson's disease: genetics and pathogenesis.

Joshua M Shulman1, Philip L De Jager, Mel B Feany

  • 1Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts 02115, USA. jshulman2@partners.org

Annual Review of Pathology
|November 2, 2010
PubMed
Summary
This summary is machine-generated.

Parkinson's disease (PD) involves more than motor symptoms, affecting the whole nervous system. Genetic discoveries are reshaping our understanding of PD causes and treatments.

More Related Videos

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

Related Experiment Videos

Last Updated: Jun 7, 2026

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease
15:09

The Use of Primary Human Fibroblasts for Monitoring Mitochondrial Phenotypes in the Field of Parkinson's Disease

Published on: October 3, 2012

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

Area of Science:

  • Neuroscience
  • Genetics
  • Pathology

Background:

  • Parkinson's disease (PD) is traditionally defined by motor symptoms and dopaminergic cell loss.
  • Emerging evidence shows widespread nervous system impact, including non-motor symptoms and pathology.
  • Genetic discoveries challenge the view of environmental factors as primary causes and blur lines between familial and sporadic PD.

Purpose of the Study:

  • To synthesize current clinical, pathological, and genetic findings on Parkinson's disease pathogenesis.
  • To challenge traditional frameworks and propose a unified concept of PD.
  • To accelerate the development of next-generation PD therapies.

Main Methods:

  • Review of recent clinical investigations into Parkinson's disease mechanisms.
  • Analysis of pathological findings, including Lewy bodies and widespread neurodegeneration.
  • Synthesis of genetic studies identifying PD-susceptibility genes and pathways.

Main Results:

  • Parkinson's disease impacts multiple nervous system regions, causing diverse non-motor symptoms.
  • Genetic factors play a significant role in PD, influencing disease mechanisms and models.
  • Mechanistic overlaps exist between Parkinson's disease and other neurodegenerative disorders.

Conclusions:

  • A unified concept of Parkinson's disease, integrating genetic and pathological insights, is emerging.
  • Understanding the widespread impact and genetic underpinnings of PD is crucial for therapeutic advancement.
  • Future research should focus on these integrated lessons to design effective PD therapies.