Related Experiment Video
Updated: Jun 7, 2026

Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
Published on: January 7, 2020
The unsettled baby: crying out for an integrated, multidisciplinary primary care approach
Pamela S Douglas1, Harriet Hiscock
1Gladstone Road Medical Centre, Brisbane, QLD, Australia. pameladouglas@uq.edu.au
Insights
Unsettled infant behavior is common, often misdiagnosed, and can lead to serious risks. An integrated, evidence-based approach is needed for effective management of infant fussiness and maternal well-being.
Area of Science:
- Pediatrics
- Neonatal Care
- Maternal Health
Background:
- Unsettled infant behavior is a prevalent clinical issue with significant risks, including maternal depression and child abuse.
- Parents frequently encounter challenges in accessing suitable care and receive inconsistent advice regarding infant fussiness.
- Organic causes are rare, yet conditions like reflux, food allergies, and lactose intolerance are often misdiagnosed in unsettled infants.
Purpose of the Study:
- To highlight the need for an integrated, evidence-based, multidisciplinary primary care approach for managing unsettled infants and their mothers.
- To emphasize the risks associated with misdiagnosing and mistreating infant unsettled behavior.
- To advocate for avoiding acid-suppressive medications in unsettled infants due to lack of evidence and potential risks.
Main Methods:
- Literature review on unsettled infant behavior, common misdiagnoses, and treatment efficacy.
- Analysis of risks associated with delayed or incorrect diagnosis and management.
- Discussion of the importance of addressing breastfeeding difficulties and cow's milk allergy.
Main Results:
- Unsettled behavior in infants is often a transient neurodevelopmental phase peaking around 6 weeks.
- Acid-suppressive medications lack evidence for treating unsettled behavior and may pose risks.
- Failure to identify correctable issues like breastfeeding problems or cow's milk allergy can lead to long-term maternal-infant interaction issues.
Conclusions:
- An integrated, evidence-based, multidisciplinary primary care model is a priority for managing unsettled infants and supporting maternal mental health.
- Accurate diagnosis and timely intervention are crucial to prevent long-term negative outcomes for both infant and mother.
- Further investigation into the potential link between proton-pump inhibitors and food allergies is warranted before their use in this population.
Abstract:
Unsettled behaviour in the first few months of life is a common clinical problem, with the associated risks of postnatal depression, premature cessation of breastfeeding, long-term psychological disturbance, and child abuse. Parents of new babies complain of difficulty accessing appropriate care and receiving conflicting advice. Although organic disturbance is implicated in only 5% of cases, gastro-oesophageal reflux disease, food allergies and lactose intolerance are often mistakenly diagnosed in unsettled babies. There is no evidence that acid-suppressive medications help in treating unsettled behaviour and, until the hypothesis that proton-pump inhibitors may predispose to food allergies has been properly investigated, treatment with acid-suppressive medications should be avoided in this population. Although unsettled behaviour in infants is commonly a transient neurodevelopmental phenomenon that peaks at 6 weeks of age, failure to diagnose other correctable problems, including breastfeeding difficulty and cows milk allergy, risks entrenching anxiety and disrupted mother-infant interactions in the long term. In the current climate of health system reform, the design and evaluation of an integrated, evidence-based, multidisciplinary primary care approach to management of unsettled babies and their mothers is a priority.
Related Concept Videos
Interdisciplinary Care: The Health Care Team-I
Physicians
The physician's primary responsibility is to diagnose illness and direct the medical or surgical treatment of the condition. The authority to admit patients to a healthcare agency or institution and practice care within that setting is granted to physicians by the healthcare agency or institution itself.
Interdisciplinary Care: The Health Care Team-II
Physical Therapist
A physical therapist (PT) aims to restore function or prevent additional impairment in a patient following an injury or disease. Massage, heat, cold, water, sonar waves, exercises, and electrical stimulation are some treatments used by PTs to treat...
Primary Healthcare Services
In 1978, international leaders convened in Alma-Ata, Kazakhstan, for what would be a pivotal event in global health. The Alma-Ata Declaration was the first to call...
Specialized Care Centers and Settings-I
Daycare centers
They provide several functions. Some facilities care for healthy newborns and children whose parents work, while others are medically focused and care for...
Introduction To Health Care Delivery System
The Institute of Medicine (IOM) advocates for a patient-centered, effective, safe, timely, equitable, and effective healthcare system. The National Priorities...
Secondary Healthcare System
