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Published on: August 19, 2020
Oxygen administration in the care of neonates: a double-edged sword
1University of Pennsylvania School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19072, USA. dennery@email.chop.edu
Objective:
To evaluate the use of oxygen in neonates in the past, present and future.
Data Sources:
The data are mainly from Pubmed with relevant published articles from the 1940s to the present with some information gathered from web searches.
Study Selection:
Studies evaluating the use of oxygen in premature and term infants through history with original milestone articles included.
Results:
There are still many unknowns about the proper use of oxygen in preterm and term infants but many studies suggest that both liberal use (resulting in a blood oxygen saturation of greater than 94%) as well as restrictive use (resulting in a blood oxygen saturation of less than 80% - 85%) are detrimental and have long term consequences on the infant.
Conclusions:
Definitive studies evaluating the appropriate concentration and duration of supplemental oxygen are ongoing and will help in the management of term and preterm infants requiring oxygen.
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