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Updated: Jun 7, 2026

Microscopy-based Assays for High-throughput Screening of Host Factors Involved in Brucella Infection of Hela Cells
Published on: August 5, 2016
Cell-mediated immunity in human brucellosis
Panagiotis Skendros1, Georgios Pappas, Panagiota Boura
1First Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis, Greece. pskendro@med.duth.gr
Abstract:
Brucella can parasitize within human antigen-presenting cells modifying phagocytosis, phagolysosome fusion, antigen presentation, cytokine secretion, and apoptosis. Subversion of innate immune mechanisms by Brucella leads to defective Th1 immune responses and T-cell anergy in chronic brucellosis patients. This review summarizes the cellular immune responses in brucellosis, based on data derived exclusively from human cells or cell lines.
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