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Stromelysin/transin and tumor progression.

L M Matrisian¹, G T Bowden

¹Department of Cell Biology, Vanderbilt University, Nashville, TN 37232.

Seminars in Cancer Biology

|April 1, 1990

Summary

Transin, a metalloproteinase, is regulated by oncogenes and growth factors, and its expression links to cancer progression. Its activity is controlled transcriptionally, via precursor processing, and by inhibitors, highlighting its role in tumor development.

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Area of Science:

Biochemistry
Molecular Biology
Oncology

Background:

Transin is an oncogene-inducible protein and the rat homologue of stromelysin.
Stromelysin is an extracellular matrix-degrading metalloproteinase.
Its expression is associated with tumor progression, suggesting a role in cancer.

Purpose of the Study:

To investigate the regulatory mechanisms of transin/stromelysin activity.
To understand the role of transin/stromelysin in cancer progression.

Main Methods:

Analysis of transcriptional regulation by oncogenes, growth factors, and inhibitors.
Investigation of post-translational processing of the inactive precursor form.
Assessment of modulation by tissue inhibitors of metalloproteinases (TIMPs).

Main Results:

Transin/stromelysin is transcriptionally regulated by oncogenes, tumor promoters, and growth factors.
Negative regulation occurs with glucocorticoids and transforming growth factor-beta.
Protease activity is controlled by precursor processing and TIMPs.

Conclusions:

Transin/stromelysin activity is multi-level regulated.
Its association with tumor progression underscores its importance in cancer.

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