Related Experiment Video
Updated: Jun 7, 2026

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
Published on: April 2, 2021
Proliferative retinopathy in a child with congenital cyanotic heart disease
Neha Goel1, Vinod Kumar, Anisha Seth
1Guru Nanak Eye Centre, Maulana Azad Medical College, New Delhi, India. nehadoc@hotmail.com
Insights
Congenital cyanotic heart disease can cause widespread ischemia. This study identifies proliferative retinopathy, a previously unnoted ocular complication, in a child with this condition.
Area of Science:
- Ophthalmology
- Cardiology
- Pediatrics
Background:
- Congenital cyanotic heart disease involves mixed blood flow, leading to systemic ischemia.
- Ocular complications are known in these patients, but proliferative retinopathy is not well-documented.
Observation:
- A case study of a child with congenital cyanotic heart disease was conducted.
- The child presented with unusual fundus findings.
Findings:
- Multiple fibrovascular fronds were observed on the fundus.
- These findings are consistent with proliferative retinopathy.
Implications:
- This suggests proliferative retinopathy may be an unrecognized ocular manifestation of congenital cyanotic heart disease.
- Further research is needed to understand the prevalence and pathogenesis of this finding.
Abstract:
In congenital cyanotic heart disease, oxygenated and deoxygenated blood mixes, and oxygen saturation of the arterial blood is not maintained. As a result, an ischemic environment prevails in the entire body. While various ocular findings have been described in patients with cyanotic heart disease, proliferative retinopathy has not been previously noted. We report a child with congenital cyanotic heart disease and multiple fibrovascular fronds over the fundus consistent with proliferative retinopathy.
Related Concept Videos
Diabetic Retinopathy
Photoreceptors and Visual Pathways
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Rheumatic Heart Disease I: Introduction

