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Updated: Jun 7, 2026

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
Published on: July 20, 2016
N⁶-Alkyladenosines: Synthesis and evaluation of in vitro anticancer activity
Roberta Ottria1, Silvana Casati, Erika Baldoli
1Dipartimento di Scienze Cliniche 'Luigi Sacco', Università degli Studi di Milano, Italy.
Abstract:
A series of adenosine analogues differently substituted in N⁶-position were synthesized to continue our studies on the relationships between structure and biological activity of iPA. The structures of the compounds were confirmed by standard studies of ¹H NMR, MS and elemental analysis. These molecules were then evaluated for their anti-proliferative activity on bladder cancer cells. We found that some of these compounds possess anti-proliferative activity but have no effect on cell invasion and metalloprotease activity.
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