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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material for adaptive...
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Related Experiment Video

Updated: Jun 7, 2026

Protocols for Investigating the Host-tissue Distribution, Transmission-mode, and Effect on the Host Fitness of a Densovirus in the Cotton Bollworm
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Protocols for Investigating the Host-tissue Distribution, Transmission-mode, and Effect on the Host Fitness of a Densovirus in the Cotton Bollworm

Published on: April 12, 2017

Positive reinforcement for viruses.

Frederic Vigant1, Michael Jung, Benhur Lee

  • 1Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Chemistry & Biology
|November 2, 2010
PubMed
Summary
This summary is machine-generated.

New antivirals target the critical membrane curvature transition during virus-cell fusion. These rigid fusion inhibitors show broad activity against enveloped viruses, offering a promising therapeutic strategy.

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Published on: August 22, 2018

Area of Science:

  • Biophysics
  • Virology
  • Drug Discovery

Background:

  • Virus-cell membrane fusion is essential for viral entry.
  • This process involves a critical shift in membrane curvature from positive to negative.
  • Understanding and targeting this transition is key for antiviral development.

Purpose of the Study:

  • To design and characterize novel antiviral compounds.
  • To investigate the targeting of the virus-cell membrane fusion curvature transition.
  • To assess the efficacy of these compounds against enveloped viruses.

Main Methods:

  • Design of rigid amphipathic molecules.
  • Biophysical assays to study membrane curvature.
  • Antiviral activity testing against various enveloped viruses.

Main Results:

  • A class of rigid amphipathic fusion inhibitors was successfully designed.
  • These inhibitors effectively target the critical membrane curvature transition.
  • Broad-spectrum antiviral activity was demonstrated against multiple enveloped viruses.

Conclusions:

  • Targeting the membrane curvature transition is a viable antiviral strategy.
  • The developed fusion inhibitors represent a promising new class of therapeutics.
  • These findings open avenues for broad-spectrum antiviral drug development.