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Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

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Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria
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Shrinking the malaria map: progress and prospects.

Richard G A Feachem1, Allison A Phillips, Jimee Hwang

  • 1The Global Health Group, University of California, San Fransisco, San Francisco, CA 94105, USA. feachemr@globalhealth.ucsf.edu

Lancet (London, England)
|November 2, 2010
PubMed
Summary
This summary is machine-generated.

Malaria elimination has been achieved by many countries, with 32 currently pursuing this goal. This series examines the technical, operational, and financial aspects of malaria elimination, highlighting challenges and benefits.

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Last Updated: Jun 7, 2026

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Area of Science:

  • Global Health
  • Infectious Disease Epidemiology
  • Public Health Policy

Background:

  • Historically, approximately 50% of countries have successfully eliminated malaria over the last 150 years.
  • Currently, 99 countries remain endemic for malaria, with 67 actively controlling the disease and 32 pursuing elimination strategies.
  • This series focuses on the multifaceted dimensions of malaria elimination, encompassing technical, operational, and financial considerations.

Purpose of the Study:

  • To review definitions of malaria elimination and the preceding state of controlled low-endemic malaria.
  • To present feasibility assessments as a critical step for countries transitioning towards malaria elimination.
  • To outline the characteristics of countries that have successfully eliminated malaria and contrast them with past efforts.

Main Methods:

  • Review of definitions and epidemiological states related to malaria elimination.
  • Analysis of feasibility assessments for transitioning from malaria control to elimination.
  • Comparative analysis of countries currently pursuing malaria elimination versus those with historical elimination attempts.

Main Results:

  • Identified key characteristics of 32 malaria-eliminating countries.
  • Highlighted challenges and risks, including Plasmodium vivax, drug/insecticide resistance, and potential resurgence.
  • Outlined the benefits of malaria elimination as a regional and global public good.

Conclusions:

  • Malaria elimination is a feasible but challenging endeavor requiring sustained investment and vigilance.
  • Understanding the technical, operational, and financial dimensions is crucial for successful elimination strategies.
  • Priorities for the next decade should focus on addressing identified challenges and consolidating gains for long-term malaria eradication.