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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 7, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Metastatic basal cell carcinoma.

Yadranko Ducic1, Diego E Marra

  • 1Otolaryngology and Facial Plastic Surgery Associates, Fort Worth, Texas, USA. yducic@sbcglobal.net

American Journal of Otolaryngology
|November 2, 2010
PubMed
Summary
This summary is machine-generated.

Metastatic basal cell carcinoma (BCC) of the head and neck is rare. Surgical resection with or without radiation therapy effectively treats metastatic BCC, with no disease-related deaths observed in this series.

Related Experiment Videos

Last Updated: Jun 7, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Area of Science:

  • Oncology
  • Dermatology
  • Head and Neck Surgery

Background:

  • Metastatic basal cell carcinoma (BCC) originating in the head and neck is uncommon.
  • Early involvement of the skull base or dura necessitates thorough metastatic evaluation and surveillance.

Purpose of the Study:

  • To review a series of head and neck metastatic basal cell carcinoma cases.
  • To evaluate treatment outcomes for metastatic BCC.

Main Methods:

  • Retrospective review of documented metastatic BCC cases from head and neck primaries.
  • Inclusion criteria: primary BCC in the head and neck region, metastatic disease presentation.

Main Results:

  • Nine patients were reviewed.
  • Metastatic sites included lungs (4) and parotid glands (5); 5 had skull base extension.
  • All lesions were surgically excised, with 6 receiving adjuvant radiation therapy.

Conclusions:

  • Metastatic BCC from head and neck primaries is rare but requires vigilant surveillance.
  • Surgical resection combined with radiation therapy is an effective treatment modality.
  • Chemotherapy is not favored for resectable metastatic BCC.