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Updated: Jun 7, 2026
13:07
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Multi-scale interaction of particulate flow and the artery wall.
I Halliday1, M Atherton, C M Care
1Materials and Engineering Institute, Sheffield Hallam University, Sheffield, UK. i.halliday@shu.ac.uk
Medical Engineering & Physics
|November 2, 2010
Summary
This study explores the physical and biological factors driving atherosclerotic plaque initiation. It proposes a multi-scale modeling strategy to understand blood flow
Area of Science:
- Cardiovascular Science
- Biophysics
- Computational Biology
Background:
- Atherosclerosis involves complex physical and biological processes at the vascular endothelium.
- Understanding plaque initiation requires considering multiple spatial and temporal scales.
- Blood flow dynamics, particularly particulate flow, play a crucial role.
Purpose of the Study:
- To discuss the fundamental science behind atherosclerotic plaque initiation.
- To propose a novel multi-scale modeling strategy for studying atherosclerosis.
- To bridge the understanding between particulate flow and endothelial cell state.
Main Methods:
- Review of existing models of vessel wall evolution.
- Identification of key physical and biological processes involved.
- Development of a multiply-coupled, multi-scale modeling framework (qualitative validation).
Main Results:
- Detailed discussion of scale-dependent processes in plaque formation.
- Emphasis on the non-continuum nature of blood flow and its impact.
- Validation of core components for a coupled modeling approach.
Conclusions:
- A multi-scale modeling strategy is proposed to analyze atherosclerosis.
- This approach aims to quantitatively link particulate flow with endothelial state.
- Future work should focus on patient-specific, quantitative understanding.
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