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Related Experiment Video

Updated: Jun 7, 2026

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

Obesity in single gene disorders.

Philip L Beales¹

¹Molecular Medicine Unit, UCL Institute of Child Health and Great Ormond Street Hospital for Children, London, United Kingdom.

Progress in Molecular Biology and Translational Science

|November 2, 2010

Summary

Obesity has a strong genetic component, with research identifying key genes and pathways regulating body weight. Understanding these genetic factors, particularly monogenic diseases, is crucial for managing obesity as a disease.

Area of Science:

Genetics
Endocrinology
Metabolic Diseases

Background:

Obesity heritability estimated at 0.80 in the 1980s highlighted significant genetic influences.
Discovery of leptin and its role in body weight homeostasis advanced understanding of metabolic regulation.
Despite progress, effective management of obesity, a complex disease-related state, remains a challenge.

Purpose of the Study:

To examine the evidence for genetic factors contributing to obesity.
To focus on the significant role of monogenic diseases in obesogenic processes.

Main Methods:

Review of existing data on obesity and genetic factors.
Analysis of the impact of monogenic diseases on obesity.

Main Results:

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Last Updated: Jun 7, 2026

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

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Published on: April 4, 2012

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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Significant genetic origins of obesity confirmed.
Monogenic diseases play a substantial role in obesity development.

Conclusions:

Understanding genetic underpinnings, especially monogenic forms, is vital for combating obesity.
Further research into genetic factors is necessary for effective obesity management strategies.