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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Related Experiment Video

Updated: Jun 7, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
06:54

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

Published on: February 13, 2026

Multiscale modeling of bone tissue with surface and permeability control.

Pedro Gonçalves Coelho1, Paulo Rui Fernandes, Helder Carriço Rodrigues

  • 1FCT, Universidade Nova de Lisboa, Caparica, Portugal.

Journal of Biomechanics
|November 2, 2010
PubMed
Summary

This study introduces a multiscale bone remodeling model, simulating whole bone density and trabecular structure. The model accurately predicts bone density and ensures pore interconnectivity, aiding in defining bone quality and diagnosing osteoporosis.

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Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model
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Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model

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Last Updated: Jun 7, 2026

Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
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Multimodal Approach to Assess Bone Regeneration and Scaffold Performance

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Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model
07:29

Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model

Published on: September 27, 2024

Area of Science:

  • Biomechanics
  • Materials Science
  • Computational Biology

Background:

  • Biological materials exhibit hierarchical structures across multiple scales.
  • Bone's complex hierarchical nature presents challenges for biomechanical modeling and understanding adaptation.

Purpose of the Study:

  • To develop and validate a multiscale model for bone tissue adaptation.
  • To simulate bone remodeling at both whole bone (macroscale) and trabecular architecture (microscale) levels concurrently.

Main Methods:

  • A multiscale model was developed, integrating macroscale bone density distribution with microscale trabecular structure properties (surface density, permeability).
  • Bone remodeling was formulated as a material distribution problem across both scales.
  • A 3D simulation of human femur adaptation was performed to test the model.

Main Results:

  • The model accurately predicted human femur bone density distribution.
  • Microstructural permeability ensured pore interconnectivity, crucial for vascularization and nutrient transport.
  • The model demonstrated flexibility in controlling morphometric parameters of trabecular structure.

Conclusions:

  • The multiscale model provides a robust framework for understanding bone tissue adaptation.
  • This model can be a valuable tool for assessing bone quality and aiding in osteoporosis diagnosis.
  • The model supports the development of novel bone substitutes and regenerative therapies.