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Updated: Jun 7, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Novel and efficient synthesis and antifungal evaluation of 2,3-functionalized cholestane and androstane derivatives
Branko S Jursic1, Sunil Kumar Upadhyay, Clinton C Creech
1Department of Chemistry, University of New Orleans, New Orleans, LA 70148, USA.
Abstract:
Synthetic modifications of cholesterol and other traditional steroid molecules have become a promising area for the exploration and development of novel antifungal agents, especially with respect to the development of fatty-acid esters of steroids. In addition, 2,3-functionalized steroids are also compounds with potentially interesting biological properties and proper functionalization of 2,3-steroids can lead to the development of efficient syntheses of building blocks for novel fatty-acid esters of steroids. In this Letter, we outline a novel and efficient approach to the synthesis of 2,3-functionalized cholestane and androstane derivatives and present their promising preliminary antifungal activities against a number of fungal species.
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