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Antiproliferative effects of rapamycin and celecoxib in angiosarcoma cell lines

Annika Bundscherer1, Thomas Vogt, Gudrun Köhl

  • 1Department of Dermatology, University of Regensburg, Regensburg, Germany.

Anticancer Research
|November 2, 2010
PubMed
Abstract

Insights

Celecoxib (COX2 inhibitor) and rapamycin (mTOR antagonist) effectively inhibited angiosarcoma cell growth. Combining these drugs showed additive effects in some cell lines, suggesting their potential in angiosarcoma treatment.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Established drugs can possess anticancer properties beyond their primary indications.
  • Angiosarcoma is a rare and aggressive cancer with limited treatment options.

Purpose of the Study:

  • To evaluate the efficacy of celecoxib (COX2 inhibitor) and rapamycin (mTOR antagonist) against angiosarcoma cell lines.
  • To determine if combining these agents yields synergistic or additive effects.

Main Methods:

  • Utilized three distinct angiosarcoma cell lines: ASM, ISOS 1, and ISO HAS.
  • Assessed cell proliferation using the bromodeoxyuridine (BrdU) incorporation assay.

Main Results:

  • Both celecoxib and rapamycin demonstrated dose-dependent inhibition of angiosarcoma cell proliferation.
  • Additive growth inhibitory effects were observed when combining celecoxib and rapamycin in ASM and ISOS 1 cell lines, but not in ISO HAS.

Conclusions:

  • Subtoxic doses of rapamycin and celecoxib can significantly inhibit angiosarcoma cell proliferation.
  • mTOR antagonists and COX2 inhibitors show promise for palliative angiosarcoma treatment due to their direct and stroma-mediated anticancer activities.

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