Related Experiment Video
Updated: Jun 7, 2026
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
L-type amino-acid transporter 1 expression predicts the response to preoperative hyperthermo-chemoradiotherapy for
Takeshi Ebara1, Kyoichi Kaira, Jun-Ichi Saito
1Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan. tebara@med.gunma-u.ac.jp
Aim:
To evaluate whether expression of L-type amino acid transporter 1 (LAT1) in pretreatment rectal cancer biopsies is predictive of tumour response to neoadjuvant hyperthermo-chemoradiotherapy (HCRT).
Patients And Methods:
Forty-four patients with rectal adenocarcinoma who received neoadjuvant HCRT were investigated. LAT1 expression was immunohistochemically evaluated using pretreatment biopsies. The operation was performed after 2-3 months following HCRT and each resected specimen was graded by the histological criteria of the Japanese Classification of Colorectal Carcinoma.
Results:
A positive LAT1 expression was recognized in 50.0% (22/44) of patients. Resected specimens were divided into 2 groups according to the histological grading criteria: good response (n=29) and poor response (n=15). LAT1-negative tumours had an 81.8% probability of good response and 18.2% probability of poor response. LAT1 expression showed marginally significant association with response to HCRT (p=0.05).
Conclusion:
LAT1 may be a useful predictive marker of response to HCRT in rectal cancer.
Related Concept Videos
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
02:57Targeted Cancer Therapies
There are several types of targeted therapies against specific...