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Brainstem changes in 5-HT1A receptor availability during migraine attack.

G Demarquay1, A Lothe, J P Royet

  • 1Service de Neurologie, Hôpital de la Croix-Rousse France, Lyon, France. genevieve.demarquay@chu-lyon.fr

Cephalalgia : an International Journal of Headache
|November 2, 2010
PubMed
Summary
This summary is machine-generated.

Migraine attacks show increased 5-HT(1A) receptor availability in the brainstem's pontine raphe. This finding highlights the role of serotonin 5-HT(1A) receptors in the early stages of migraine.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Medical Imaging

Background:

  • Serotonin 5-HT(1A) receptors regulate central serotoninergic tone.
  • Abnormal brain serotonin turnover is suspected in migraineurs.
  • 5-HT(1A) receptor availability during migraine attacks requires investigation.

Purpose of the Study:

  • To investigate the availability of serotonin 5-HT(1A) receptors during migraine attacks.
  • To explore the role of 5-HT(1A) receptors in the pathophysiology of migraine.

Main Methods:

  • Positron emission tomography (PET) with the selective 5-HT(1A) antagonist [(18)F]MPPF was used.
  • Ten migraine patients and ten controls underwent PET scans after olfactory stimulation.
  • Four patients experienced migraine attacks during the PET study.

Main Results:

  • Increased [(18)F]MPPF binding potential (BP(ND)) in the pontine raphe during migraine attacks compared to controls and headache-free migraineurs.
  • Elevated [(18)F]MPPF BP(ND) in the left orbitofrontal cortex, precentral gyrus, and temporal pole during attacks.
  • No significant differences in [(18)F]MPPF BP(ND) between headache-free migraineurs and controls.

Conclusions:

  • The study emphasizes the involvement of 5-HT(1A) receptors in the pontine raphe nuclei during the early phase of migraine attacks.
  • Findings suggest a role for 5-HT(1A) receptors in the ictal changes associated with migraine.