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Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population
Lucia Corrado1, Laura Bergamaschi, Nadia Barizzone
1Department of Medical Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont, Novara, Italy.
Background:
The T allele of rs9657904 within the CBLB gene was recently found to be significantly associated with multiple sclerosis (MS) in a genome-wide association study in Sardinia.
Objective:
To replicate this association in an independent population with a different genetic background.
Methods:
The rs9657904 variant was typed in a sample of 1435 cases and 1466 controls from the Italian mainland.
Results:
It was found that in this sample also, the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35 × 10(-5)) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52).
Conclusion:
These data provide further evidence of the association of MS disease with variation within CBLB.
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