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Related Experiment Video

Updated: Nov 21, 2025

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

[Animal models for vascular calcification].

Koji Ikeda¹, Yusuke Nakagawa, Hiroaki Matsubara

¹Deparment of Cardiology, Kyoto Prefectural University of Medicine.

Clinical Calcium

|November 2, 2010

Summary

This summary is machine-generated.

Animal models are crucial for understanding vascular calcification (VC) mechanisms and developing treatments. Gene-modified mice and inducible models in wild-type animals offer valuable insights for advancing VC therapies.

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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Area of Science:

Biomedical Research
Cardiovascular Biology
Translational Medicine

Context:

Vascular calcification (VC) is a significant contributor to cardiovascular disease.
Understanding the molecular mechanisms of VC is essential for therapeutic development.
Animal models provide critical tools for studying VC pathogenesis.

Purpose:

To review the utility of animal models in vascular calcification (VC) research.
To highlight the role of gene-modified mice and inducible models in elucidating VC mechanisms.
To emphasize the importance of these models for developing novel VC therapies.

Summary:

Analysis of animal models is indispensable for elucidating the molecular mechanisms underlying vascular calcification (VC).
Gene-modified mice exhibiting VC and inducible VC models in wild-type animals represent key research tools.
These models demonstrate that bone-calcification regulatory factors play a crucial role in VC, mirroring their function in bone.
Inducible VC models are vital for developing preventive and therapeutic strategies for VC.

Impact:

Advances the understanding of vascular calcification (VC) at a molecular level.
Facilitates the development of targeted therapies for vascular calcification (VC).
Accelerates progress in preventing and treating cardiovascular diseases associated with VC.