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Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Chickenpox

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Accessory Structures of the Skin: Sebaceous Glands

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Updated: Jun 7, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Pyoderma gangraenosum.

Uwe Wollina1, Gunter Haroske

  • 1Department of Dermatology and Allergology, Hospital Dresden-Friedrichstadt, Academic Teaching Hospital of the Technical University of Dresden, Friedrichstrasse 41, 01067 Dresden, Germany. wollina-uw@khdf.de

Current Opinion in Rheumatology
|November 2, 2010
PubMed
Summary
This summary is machine-generated.

Pyoderma gangraenosum (PG) understanding is advancing, with new insights into its link with inflammatory bowel disease. Current treatments include corticosteroids and newer agents, but more trials are needed for optimal patient outcomes.

Related Experiment Videos

Last Updated: Jun 7, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

  • Dermatology and Immunology
  • Gastroenterology

Background:

  • Pyoderma gangraenosum (PG) is a rare, inflammatory neutrophilic dermatosis.
  • It is frequently associated with systemic diseases, most notably inflammatory bowel disease (IBD).
  • Understanding the underlying pathology and therapeutic interventions for PG is crucial for patient management.

Purpose of the Study:

  • To review current understanding of pyoderma gangraenosum pathogenesis.
  • To illustrate clinical presentations and associations of PG.
  • To discuss established and emerging therapeutic strategies for PG.

Main Methods:

  • Literature review of current research on pyoderma gangraenosum.
  • Analysis of clinical observations and associations.
  • Evaluation of therapeutic interventions, including corticosteroids, immunosuppressants, and novel agents.

Main Results:

  • The PEST family of protein tyrosine phosphatases and PSTPIP1 are implicated in PG pathogenesis.
  • PG is a common extra-intestinal manifestation of IBD, with specific risk factors identified.
  • Systemic corticosteroids are first-line treatment; cyclosporine A, TNF-alpha inhibitors, and other agents show promise.
  • Topical tacrolimus is effective for localized disease, but controlled trials are needed for newer therapies.

Conclusions:

  • Improved understanding of PG pathology and drug development will benefit patients.
  • Systemic immunosuppressants remain standard care, with localized treatments for specific cases.
  • Further controlled trials are warranted for evaluating novel therapeutic agents in pyoderma gangraenosum.