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SRD5A2 gene mutations--a population-based review
Ratika Samtani1, Minu Bajpai, P K Ghosh
1Research Scholar, Department of Anthropology, University of Delhi, Delhi 110007, India.
Abstract:
Knowledge of steroid 5 alpha-reductase type 2 (SRD5A2) gene mutations is expanding, and its role has been implicated in various disease susceptibilities concerning reproductive health. Extensive research has revealed the tendency for specific SRD5A2 gene mutations to be passed along certain racial, ethnic and geographically isolated groups, which suggests population specificity of these mutations. The review provides evidence of variation in the mutational spectrum of the SRD5A2 gene leading to population-specific high prevalence of characteristic disease or phenotypic expression.
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