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Related Experiment Video

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Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors

Published on: September 27, 2019

Toll-like receptor 7 mediates pruritus.

Tong Liu1, Zhen-Zhong Xu, Chul-Kyu Park

  • 1Sensory Plasticity Laboratory, Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Nature Neuroscience
|November 2, 2010
PubMed
Summary

Functional Toll-like receptor 7 (TLR7) in sensory neurons induces itch but not pain. This finding suggests TLR7 as a potential therapeutic target for treating itch in skin conditions.

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A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
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Last Updated: Jun 7, 2026

Cheek Injection Model for Simultaneous Measurement of Pain and Itch-related Behaviors
04:59

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Published on: September 27, 2019

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08:35

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Published on: March 17, 2015

Area of Science:

  • Neuroscience
  • Immunology
  • Dermatology

Background:

  • Toll-like receptors (TLRs) are key regulators of innate immunity, primarily found on immune cells.
  • Their role in sensory neurons and non-immune functions is an emerging area of research.

Purpose of the Study:

  • To investigate the role of Toll-like receptor 7 (TLR7) in sensory neurons.
  • To determine if TLR7 mediates itch (pruritus) or pain sensations.

Main Methods:

  • Expression analysis of TLR7 in C-fiber primary sensory neurons.
  • Assessment of itch and pain behaviors in mice lacking functional TLR7.

Main Results:

  • Functional TLR7 was identified in C-fiber primary sensory neurons.
  • TLR7 deficiency in mice abolished itch induction without affecting mechanical, thermal, inflammatory, or neuropathic pain responses.

Conclusions:

  • TLR7 plays a critical role in mediating itch in mice.
  • Targeting TLR7 presents a potential therapeutic strategy for managing pruritus in various skin diseases.