Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

On the Distribution of Free-Energy in Metabolism.

bioRxiv : the preprint server for biology·2026
Same author

Extending the evidence for Scrambler Therapy to reduce pain in chemotherapy-induced peripheral neuropathy.

International review of psychiatry (Abingdon, England)·2026
Same author

Convergence of TMS Sites and Lesion Locations Associated With Nicotine Addiction Improvement on a Common Brain Circuit.

The American journal of psychiatry·2026
Same author

Parkinson's disease severity is encoded by non-linear oscillatory interactions across cortical-subcortical networks.

Scientific reports·2026
Same author

Compounding or confounding?-addressing context-specific disparities in access to outpatient specialty palliative care.

Annals of palliative medicine·2026
Same author

A Canonical Neural Map and Its Deviations Shape Parkinson's Disease Phenotypes.

Research square·2026

Related Experiment Video

Updated: Jun 7, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

QEEG Measures in Huntington's Disease: A Pilot Study.

Aimee Hunter1, Yvette Bordelon, Ian Cook

  • 1UCLA School of Medicine; Department of Neurology UCLA; UCLA Semel Institute and UCLA.

Plos Currents
|November 2, 2010
PubMed
Summary

Quantitative electroencephalography (QEEG) reveals brain function changes in Huntington's Disease (HD). These QEEG measures correlate with disease severity and genetic factors, suggesting potential as biomarkers for HD progression.

More Related Videos

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Related Experiment Videos

Last Updated: Jun 7, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Area of Science:

  • Neuroscience
  • Genetics
  • Biomarker Discovery

Background:

  • Huntington's Disease (HD) is a neurodegenerative disorder characterized by trinucleotide repeats.
  • Structural brain changes via MRI are known indicators of HD progression.
  • Neurophysiological measures may provide additional insights into HD onset and progression.

Purpose of the Study:

  • To investigate quantitative electroencephalography (QEEG) power measures as biomarkers for brain function in HD.
  • To assess the relationship between QEEG findings, HD severity (UHDRS), and CAG repeat numbers.
  • To explore QEEG's potential in detecting early functional changes in premanifest HD.

Main Methods:

  • Utilized resting-state quantitative electroencephalography (QEEG) power measures.
  • Compared QEEG data between 27 HD subjects and 15 healthy controls.
  • Correlated QEEG features with Unified Huntington Disease Rating Scale (UHDRS) subscales and CAG repeat counts.

Main Results:

  • HD subjects exhibited increased delta power globally compared to controls.
  • HD subjects showed a loss of the typical anterior-posterior (AP) gradient in relative alpha and delta power.
  • Loss of AP gradient in alpha and delta power correlated with reduced functional capacity, cognitive decline, motor symptoms, and higher CAG repeat numbers.

Conclusions:

  • QEEG power measures may serve as valuable biomarkers for brain function perturbations in HD.
  • These QEEG findings correlate with both functional status and genetic factors in HD.
  • Early detection of brain functional abnormalities in premanifest HD gene carriers is suggested, warranting further investigation.