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Costs and benefits of free medications after myocardial infarction
Irfan A Dhalla1, Monique A Smith, Niteesh K Choudhry
1Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Departments of Medicine and Health Policy, Management and Evaluation, University of Toronto, Toronto, ON.
Insights
Providing free secondary prevention medications to uninsured myocardial infarction patients significantly improves health outcomes and is cost-effective. This strategy enhances quality-adjusted life-years (QALYs) for patients and the healthcare system.
Area of Science:
- Health Economics
- Cardiovascular Medicine
- Public Health Policy
Background:
- Medication non-adherence after myocardial infarction (MI) limits the benefits of secondary prevention.
- Financial barriers are a key driver of non-adherence.
- This study assesses the economic impact of providing free medications to uninsured MI patients.
Purpose of the Study:
- To evaluate the cost-effectiveness of full public coverage for secondary prevention medications for MI patients lacking private insurance.
- To compare this intervention against the current healthcare system (status quo).
Main Methods:
- Economic evaluation using decision analysis and Markov modelling.
- Utilized Canadian data for cost and benefit estimations.
- Primary outcome: incremental cost-effectiveness ratio (ICER) in cost per quality-adjusted life-year (QALY) gained.
Main Results:
- Full public coverage increased QALYs (7.02 vs. 6.13) and healthcare costs ($20,423 vs. $17,173) compared to the status quo.
- The ICER for full coverage was $3,663/QALY from the healthcare system perspective, robust under sensitivity analyses.
- From a government perspective, the ICER was $12,350/QALY, sensitive to price elasticity but generally favorable.
Conclusions:
- Full public coverage of secondary prevention medications is a cost-effective strategy for uninsured MI patients in Canada.
- Public payers should consider implementing free medication programs to improve patient outcomes and reduce long-term healthcare burdens.
Background:
Although combination pharmacotherapy after myocardial infarction dramatically reduces morbidity and mortality, the full benefits of secondary prevention medications remain unrealized owing to medication non-adherence. Because financial barriers are a major determinant of non-adherence, we examined the costs and benefits of providing free medications to myocardial infarction patients who do not have private insurance and are ineligible for substantial public coverage.
Methods:
An economic evaluation combining decision analysis and Markov modelling was conducted to compare full public coverage of secondary prevention medications with the status quo. Costs and benefits were estimated using Canadian data wherever possible. The main outcome was the incremental cost-effectiveness ratio measured in cost per quality-adjusted life-year (QALY) gained.
Results:
From the perspective of the publicly funded healthcare system, full coverage resulted in greater quality-adjusted survival than the status quo (7.02 vs. 6.13 QALYs) but at increased cost ($20,423 vs. $17,173). The incremental cost-effectiveness ratio (ICER) for full coverage compared to the status quo was $3,663/QALY. This result was robust to a wide range of sensitivity analyses. In a secondary analysis from the perspective of government, the ICER for full coverage compared to the status quo was $12,350/QALY. In this analysis, the ICER was sensitive to changes in price elasticity, but remained below $50,000/QALY as long as the elasticity remained below -0.035.
Interpretation:
Public payers in Canada should consider providing secondary prevention medications to myocardial infarction patients without private insurance free of charge. Full public coverage is cost-effective compared to the status quo.
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