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Outcome of heart failure with preserved ejection fraction: a multicentre spanish registry

Juan C Castillo1, Manuel P Anguita, Manuel Jiménez

  • 1Cardiology Department, Hospital Reina Sofia, Córdoba, Spain.

Current Cardiology Reviews
|November 2, 2010
PubMed

Insights

Congestive heart failure (CHF) patients with preserved ejection fraction (≥ 45%) show similar long-term mortality and morbidity compared to those with reduced ejection fraction. Clinical characteristics differ, but outcomes are comparable.

Area of Science:

  • Cardiology
  • Heart Failure Research

Background:

  • Limited data exists on clinical features, treatment, and prognosis for congestive heart failure (CHF) with preserved left ventricular ejection fraction (LVEF).
  • Existing study results on this patient group are often conflicting.

Purpose of the Study:

  • To investigate the clinical characteristics of patients diagnosed with CHF and preserved LVEF (≥ 45%).
  • To determine the long-term prognosis and outcomes for patients with CHF and preserved LVEF.

Main Methods:

  • Prospective, multicenter study involving 4720 patients across 62 heart failure clinics in Spain (BADAPIC registry, 1999-2003).
  • Analysis of patient demographics, clinical features, and follow-up data over a mean of 40 months.
  • Multivariate analysis to identify independent predictors of mortality.

Main Results:

  • 30% of CHF patients in the registry had preserved LVEF.
  • Patients with preserved LVEF were older, more frequently female, and had higher rates of atrial fibrillation, hypertension, and non-ischemic cardiomyopathy.
  • Mortality and cardiovascular complication rates were similar between preserved and reduced LVEF groups.
  • Ejection fraction was not an independent predictor of mortality; 1- and 5-year survival rates were comparable.

Conclusions:

  • A significant proportion of heart failure patients present with preserved LVEF.
  • Despite distinct clinical profiles, patients with preserved LVEF experience similar morbidity and mortality rates compared to those with reduced LVEF.
Abstract

Keywords:
Heart failuremulticentre study.preserved systolic function

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