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04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Evaluation of the functional parameters in scleroderma cases with pulmonary involvement
Zeynep Celebi Sözener1, Gülseren Karabıyıkoğlu, Nurşen Düzgün
1Department of Chest Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey. zeynepsozener@gmail.com
Tuberkuloz Ve Toraks
|November 2, 2010
Summary
Early detection of pulmonary involvement in scleroderma is crucial. Diffusing capacity for carbon monoxide (DLCO%) is the earliest indicator, and various tests aid in monitoring patients, even those without symptoms.
Area of Science:
- Pulmonary Medicine
- Rheumatology
- Diagnostic Imaging
Background:
- Scleroderma often involves the lungs, leading to significant morbidity.
- Early identification of pulmonary involvement is critical for timely intervention and improved patient outcomes.
Purpose of the Study:
- To assess the relationship between functional changes in scleroderma patients with pulmonary involvement and diagnostic tests.
- To identify diagnostic tools for the early detection of lung complications in scleroderma.
Main Methods:
- Prospective study of 33 scleroderma patients with pulmonary involvement.
- Utilized pulmonary function tests, echocardiography, arterial blood gases, 6-minute walk tests, and high-resolution computed tomography (HRCT).
- Assessed functional status using MRC dyspnea scores, NYHA (WHO) classification, and St. George's Respiratory Questionnaire (SGRQ).
Main Results:
- Diffusing capacity for carbon monoxide (DLCO%) emerged as the earliest deteriorated parameter.
- The FVC%/DLCO% ratio showed low sensitivity for detecting pulmonary arterial hypertension noninvasively.
- SGRQ scores correlated significantly with all functional parameters in scleroderma follow-up.
Conclusions:
- Scleroderma patients require regular evaluation for pulmonary involvement, irrespective of symptoms.
- Pulmonary function tests, echocardiography, HRCT, and 6-minute walk tests are valuable for diagnosis and monitoring.
- NYHA (WHO) classification, MRC, Borg dyspnea scores, and SGRQ are helpful for early diagnosis and functional assessment.
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