Related Experiment Video
Updated: Jun 7, 2026

Extraction of Cofactor F420 for Analysis of Polyglutamate Tail Length from Methanogenic Pure Cultures and Environmental Samples
Published on: October 14, 2021
A new role for coenzyme F420 in aflatoxin reduction by soil mycobacteria
1Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6038, USA. grahamde@ornl.gov
Abstract:
Hepatotoxic aflatoxins have found a worthy adversary in two new families of bacterial oxidoreductases. These enzymes use the reduced coenzyme F420 to initiate the degradation of furanocoumarin compounds, including the major mycotoxin products of Aspergillus flavus. Along with pyridoxal 5'-phosphate synthases and aryl nitroreductases, these proteins form a large and versatile superfamily of flavin and deazaflavin-dependent oxidoreductases. F420-dependent members of this family appear to share a common mechanism of hydride transfer from the reduced, low-potential deazaflavin to the electron-deficient ring systems of their substrates.
More Related Videos
09:21Inhibition of Aspergillus flavus Growth and Aflatoxin Production in Transgenic Maize Expressing the α-amylase Inhibitor from Lablab purpureus L.
Published on: February 15, 2019
09:44RNAi-mediated Control of Aflatoxins in Peanut: Method to Analyze Mycotoxin Production and Transgene Expression in the Peanut/Aspergillus Pathosystem
Published on: December 21, 2015
Related Concept Videos
The Roles of Bacteria and Fungi in Plant Nutrition
Role of Reduced Coenzymes NADH and FADH₂
Microbial Bioremediation of Pesticides
Microbial Bioremediation of Hydrocarbons
Microbial Fermentation
Cofactors and Coenzymes