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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

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Pharmaceutical applications of cyclodextrins: basic science and product development.

Thorsteinn Loftsson¹, Marcus E Brewster

¹Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland. thorstlo@hi.is

The Journal of Pharmacy and Pharmacology

|November 3, 2010

Summary

Cyclodextrins are effective excipients for improving the solubility and dissolution of poorly soluble drugs. Their application in drug formulation is crucial for developing new parenteral and oral dosage forms, enhancing bioavailability.

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Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles

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Published on: January 22, 2015

Area of Science:

Pharmaceutical Science
Drug Delivery
Formulation Development

Background:

A significant percentage of marketed drugs (40%) and a higher proportion of drugs in development (90%) exhibit poor solubility.
Poor aqueous solubility presents a major challenge in developing effective oral and parenteral drug formulations.
Cyclodextrins offer a promising approach to overcome solubility limitations in drug development.

Purpose of the Study:

To review the fundamental science of cyclodextrins.
To present data on the development of drug formulations utilizing cyclodextrins.
To highlight cyclodextrins as a key tool for enhancing drug solubility and bioavailability.

Main Methods:

Review of scientific literature on cyclodextrin properties and applications.
Analysis of data from studies on cyclodextrin-drug complexation.
Evaluation of factors influencing the biopharmaceutical characteristics of cyclodextrin formulations.

Main Results:

Cyclodextrins are established as valuable solubilizing excipients with successful marketed products.
New product introductions confirm the significant added value of cyclodextrin-based formulations.
Understanding cyclodextrin properties and interactions is key to predicting formulation success.

Conclusions:

Cyclodextrins are essential in the formulator's toolkit for improving apparent solubility and dissolution rates.
These excipients are vital for developing dosage forms for poorly water-soluble drug candidates.
Continued research and application of cyclodextrins indicate their ongoing importance in pharmaceutical R&D and marketing.