Proton pump inhibitor use is associated with an increased risk for microscopic colitis: a case-control study
D Keszthelyi1, S V Jansen, G A Schouten
1Division of Gastroenterology-Hepatology, Department of Internal Medicine, Maastricht University Medical Centre+, Maastricht, The Netherlands. daniel.keszthelyi@intmed.unimaas.nl
Alimentary Pharmacology & Therapeutics
|November 3, 2010
Summary
Proton pump inhibitor (PPI) use is significantly associated with microscopic colitis. This study suggests PPIs may play a role in the development of this chronic diarrheal condition.
Area of Science:
- Gastroenterology
- Pharmacology
- Pathogenesis
Background:
- Microscopic colitis is a condition characterized by chronic watery diarrhea.
- Emerging evidence suggests certain medications, including proton pump inhibitors (PPIs), may contribute to its development.
Purpose of the Study:
- To investigate the association between proton pump inhibitor use and microscopic colitis.
- To compare PPI exposure in patients with microscopic colitis against matched controls.
Main Methods:
- A retrospective case-control study was conducted.
- Data from 95 microscopic colitis cases and age/gender-matched controls were analyzed.
- Exposure to PPIs and NSAIDs was assessed.
Main Results:
- Patients with collagenous colitis showed significantly higher PPI exposure (38%) compared to controls (13%).
- Adjusted odds ratio for PPI use in microscopic colitis was 4.5 (95% CI 2.0-9.5).
Conclusions:
- The findings confirm a presumed association between microscopic colitis and proton pump inhibitor use.
- This supports a potential etiological role for PPI exposure in the development of microscopic colitis.
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