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[Osteoarthritic disease: therapy with oxicam derivatives]
1Istituto di Fisiopatologia Medica, Cattedra di Geriatria, Università degli Studi G. D'Annunzio, Chieti.
Rivista Europea Per Le Scienze Mediche E Farmacologiche = European Review for Medical and Pharmacological Sciences = Revue Europeenne Pour Les Sciences Medicales Et Pharmacologiques
|August 1, 1990
Summary
This study compared tenoxicam and beta-cyclodextrin-piroxicam for osteoarthritis pain relief in elderly patients. Both drugs effectively reduced pain, with beta-cyclodextrin-piroxicam showing faster initial action and fewer gastric side effects.
Area of Science:
- Pharmacology
- Rheumatology
- Geriatrics
Background:
- Osteoarthritis is a common degenerative joint disease causing significant pain in the elderly.
- Oxicam derivatives are frequently used for pain management in osteoarthritis.
- Comparing the efficacy and safety of different oxicam formulations is crucial for clinical practice.
Purpose of the Study:
- To compare the antalgic effect and safety profile of oral tenoxicam and beta-cyclodextrin-piroxicam in elderly patients with osteoarthritis.
- To evaluate the onset and duration of pain relief provided by these two oxicam derivatives.
Main Methods:
- A 4-week, randomized study involving 40 elderly patients with osteoarthritis and intense pain.
- Patients were divided into two groups, receiving either tenoxicam capsules or beta-cyclodextrin-piroxicam tablets.
- Pain intensity and adverse events were monitored throughout the treatment period.
Main Results:
- Both tenoxicam and beta-cyclodextrin-piroxicam demonstrated excellent pain relief (antalgic effect).
- Beta-cyclodextrin-piroxicam exhibited a quicker and more pronounced effect within the first 4 hours post-administration.
- At study completion, both treatments were equally effective, though beta-cyclodextrin-piroxicam showed a greater symptomatic effect.
- Gastric adverse events were reported in 50% of the tenoxicam group and 15% of the beta-cyclodextrin-piroxicam group.
Conclusions:
- Oral beta-cyclodextrin-piroxicam offers a faster onset of pain relief compared to tenoxicam for osteoarthritis.
- Both oxicam derivatives are effective for managing osteoarthritis pain in the elderly, with beta-cyclodextrin-piroxicam having a better gastrointestinal safety profile.
- Beta-cyclodextrin-piroxicam is a potentially superior option due to its rapid action and improved tolerability.