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The relationship between postprandial bile acid concentration, GLP-1, PYY and ghrelin
R E Roberts1, C Glicksman, J Alaghband-Zadeh
1King's College London School of Medicine, UK. rachel.roberts@kcl.ac.uk
Clinical Endocrinology
|November 3, 2010
Summary
Specific bile acids influence gut hormone release. Peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) correlated with chenodeoxycholic acid (CDCA) variants, while ghrelin correlated with deoxycholic acid (DCA) variants after a test meal.
Area of Science:
- Gastroenterology
- Endocrinology
- Metabolism
Background:
- Gut hormones peptide YY (PYY) and glucagon-like peptide-1 (GLP-1) are crucial for appetite control and energy balance.
- Entero-endocrine L-cells secrete PYY and GLP-1 in response to nutrients and bile acids.
Purpose of the Study:
- To investigate the relationship between bile acid profiles and the secretion of PYY, GLP-1, and ghrelin following a standardized test meal.
Main Methods:
- Twelve healthy subjects (BMI 22.8 kg/m²) consumed a 400 kcal test meal.
- Blood samples were collected serially for 180 minutes post-meal.
- Radioimmunoassays measured PYY, GLP-1, and ghrelin; HPLC-MSMS analyzed fractionated bile acids.
Main Results:
- PYY secretion positively correlated with glycochenodeoxycholic acid (GCDCA) and taurochenodeoxycholic acid (TCDCA).
- GLP-1 secretion positively correlated with GCDCA and glycodeoxycholic acid (GDCA).
- Ghrelin secretion negatively correlated with GDCA, TCDCA, and taurodeoxycholic acid (TDCA).
Conclusions:
- PYY and GLP-1 responses are linked to specific chenodeoxycholic acid (CDCA) derivatives.
- Ghrelin release is associated with deoxycholic acid (DCA) derivatives.
- Distinct bile acids may differentially modulate entero-endocrine cell function and hormone release.
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