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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The Parathyroid Glands00:59

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
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Roles of Electrolytes: Calcium and Phosphate

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Pharmacodynamics of sustained levels of PTH following palopegteriparatide treatment in adults with hypoparathyroidism.

Journal of the Endocrine Society·2026
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Increased Prevalence of Coronary Artery Calcification in Patients with Post-Surgical Hypoparathyroidism.

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Related Experiment Video

Updated: Jun 7, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Determinants of plasma PTH and their implication for defining a reference interval.

Lars Rejnmark1, Peter Vestergaard, Lene Heickendorff

  • 1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Denmark. rejnmark@post6.tele.dk

Clinical Endocrinology
|November 3, 2010
PubMed
Summary

Vitamin D levels significantly influence parathyroid hormone (PTH) levels, impacting the upper limit of the PTH reference interval. Maintaining adequate vitamin D is crucial for accurate PTH diagnostics.

Related Experiment Videos

Last Updated: Jun 7, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Area of Science:

  • Endocrinology
  • Clinical Chemistry

Background:

  • International consensus calls for improved diagnostic sensitivity of parathyroid hormone (PTH) measurements.
  • Vitamin D insufficiency is prevalent and inversely affects PTH levels, necessitating investigation into its influence on the PTH reference interval.

Purpose of the Study:

  • To determine the 95% reference interval for plasma PTH levels in women.
  • To investigate the impact of various factors, including 25-hydroxyvitamin D (25OHD) levels, on the PTH reference interval.

Main Methods:

  • Cross-sectional study of 2316 women aged 17-84.
  • Nonparametric approach to determine the 95% reference interval for PTH.
  • Analysis of predictors including age, body weight, BMI, calcium intake, smoking, plasma calcium, and 25OHD levels.

Main Results:

  • PTH levels positively correlated with age, body weight, and BMI; inversely with calcium intake, smoking, plasma calcium, and 25OHD.
  • A 25OHD threshold of 82 nmol/l was identified below which PTH levels increased.
  • Lowering the 25OHD threshold for reference interval calculation reduced the upper PTH limit, particularly at >100 nmol/l (7.1 pmol/l).

Conclusions:

  • Factors like age, BMI, and calcium intake have minor effects on the upper PTH reference interval in women with normal renal function.
  • Vitamin D status is a key determinant of the PTH reference interval, especially at lower levels.