Related Experiment Video

Updated: Jun 7, 2026

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

Association between brachial-ankle pulse wave velocity and endothelium-dependent and -independent coronary vasomotor

Tomohide Yoshino1, Ichiro Nakae, Tetsuya Matsumoto

  • 1Departments of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Seta, Otsu, Japan.

Clinical and Experimental Pharmacology & Physiology
|November 3, 2010
PubMed

Insights

Increased brachial-ankle pulse wave velocity (baPWV) is linked to impaired coronary blood vessel function. This non-invasive measure may help assess cardiovascular risk, especially in diabetic individuals.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Physiology
  • Diagnostic Imaging

Background:

  • Coronary endothelial function and brachial-ankle pulse wave velocity (baPWV) are established predictors of cardiovascular events.
  • Understanding the interplay between vascular stiffness (baPWV) and coronary vasodilatory capacity is crucial for risk stratification.

Purpose of the Study:

  • To investigate the relationship between baPWV and both endothelium-dependent and -independent coronary vasodilatory functions.
  • To assess the clinical utility of baPWV in evaluating coronary vascular health.

Main Methods:

  • Sixty-five patients without significant coronary stenosis underwent baPWV measurement.
  • Coronary blood flow (CBF) and epicardial coronary artery diameter changes were assessed after intracoronary administration of bradykinin (endothelium-dependent), nitroglycerin, and papaverine (endothelium-independent).

Main Results:

  • A significant inverse correlation was observed between baPWV and coronary artery diameter/CBF responses to bradykinin, nitroglycerin, and papaverine.
  • Multivariate analysis identified diabetes as an independent predictor associated with higher baPWV and impaired coronary vasodilation.

Conclusions:

  • Elevated baPWV is associated with both endothelial-dependent and -independent coronary vasodilatory dysfunction.
  • baPWV serves as a valuable, non-invasive tool for assessing coronary risk factors, particularly in diabetic patients.

More Related Videos

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome06:04

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Published on: September 27, 2024

Assessing Endothelial Vasodilator Function with the Endo-PAT 200007:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Pulse01:16

Pulse

When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical indicator...
Assessment of blood pressure in brachial artery(one-step method)01:15

Assessment of blood pressure in brachial artery(one-step method)

This procedural guide systematically measures blood pressure using an oscillometric digital sphygmomanometer, emphasizing accuracy, patient safety, and comfort.
Prepare for the Procedure:
Assessment of blood pressure in brachial artery(two-step method)01:23

Assessment of blood pressure in brachial artery(two-step method)

Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...
Sites for measuring blood pressure01:21

Sites for measuring blood pressure

Blood pressure measurement is a fundamental clinical procedure, providing crucial data for assessing cardiovascular health. Among the various sites for this measurement, the brachial and popliteal arteries are predominantly utilized due to their accessibility and the reliability of their readings. This lesson delves into the anatomical significance, methodology, and considerations of measuring blood pressure at these locations.
The Brachial Artery: Primary Site for Blood Pressure Measurement
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...